• Karuna Health SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions.
• Over a decade of rigorous clinical studies in Europe and elsewhere have established SAM-e (S-adenosyl-L-methionine, an essential methylation and transulfuration cofactor) as a useful tool for supporting normal mood regulation, and joint and liver health. SAM-e increases cell membrane fluidity, up-regulates neurotransmitter receptor number, and enhances neurotransmitter receptor affinity.
• SAM-e supports healthy joints both by increasing the number of articular chondrocytes, and by stimulating the synthesis of protective sulfated proteoglycans therein. SAM-e also protects synovial cells against pro-inflammatory prostanoids, and blocks enzymes that degrade cartilage.
• SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver.

Suggested Use:

Two to four capsules daily, preferably morning and evening, or as directed.

Supplement Facts

Serving Size: 2 Capsules

Amount Per Serving %DV

Niacin (Niacinamide) … 30 mg 188%

Vitamin B6 (Pyridoxine HCl) … 2 mg … 118%

Folic Acid … 669 mcg DFE (400 mcg folic acid) … 167%

Vitamin B12 (Methylcobalamin) … 20 mcg … 833%

Choline Bitartrate … 50 mg … 9%

SAM-e (S-adenosylmethionine) … 400 mg …

Daily Value (DV) not established

Other Ingredients:

DR cap, (Hypromellose & gellan), silica, magnesium stearate (vegetable)

*These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to treat, mitigate, diagnose or cure any disease.